BioBetter Pioneers Cultivated Meat Future with Molecular Farming

Media growth start-up targets annual commercial production of 5 tons by 2025.

Kiryat Shemona, Israel - FoodTech start-up BioBetter, Ltd., opens its first food-grade pilot facility to accelerate the production of key growth factors for the cultivated meat industry. The company has pioneered a unique protein manufacturing platform for producing growth factors (GFs) using tobacco plants as self-sustained, animal-free bioreactors.

Solving bottleneck challenges
Helping cultivated meat companies offer affordable and accessible products to consumers, BioBetter is revolutionizing the future of cellular agriculture with its innovative molecular farming-based production platform. Currently, cultivated meat production processes are relatively expensive, making it a challenge to scale up and reach price parity with animal-based counterparts.

"Cultivated meat is still very expensive in comparison to conventional meat and the key is to reduce the growth medium costs to a minimum," explains Amit Yaari, Ph.D., CEO of BioBetter. "Our target is to reduce the production cost of growth factors, including insulin, a key part of the growth medium, to $1 per gram which is a 100-fold less than the going rate today."

The start-up already has achieved five impressive milestones in just the past year:

1. Production scale-up/building pilot plan
2. Commercial scale cultivation of insulin- and FGF-expressing tobacco plants
3. Reaching GF expression levels that enable a significant reduction of production costs
4. Significant regulatory progresses and advances with the Israel Ministry of Health
5. Collaboration with leading cultivated meat companies

Plant bioreactor technology
BioBetter discovered a new purpose for the traditionally shunned tobacco plants, transforming them into bioreactors for the production of GFs. These GFs play a key role in the proliferation and differentiation of cultured meat cells, allowing for the formation of authentic and well-structured muscle tissue.

Designed for both environmental safety and efficiency, these bioreactors will be grown in a large-scale, net house cultivation system. The plants are carefully engineered to prevent the escape of any transgenic material. They are induced to express growth factors only when chemically triggered, and the company exclusively uses non-food, non-feed tobacco plants to eliminate any risk of inadvertent consumption or cross-contamination of food crops.

Sustainability at the core

"Our holistic approach not only underscores our commitment to safety and environmental responsibility but also streamlines regulatory processes," reveals Dana Yarden, M.D., co-founder of BioBetter. "Our commitment to sustainability shines through in every facet of our operations. We plan to use recycled and low-quality water for irrigation, minimize nitrogen fertilizer use, and reduce emissions and environmental impact.

The newly established pilot plant has the capacity to process 100kg of tobacco plant-derived GFs daily. Constructed in adherence to the highest quality standards, the facility meets all regulatory requirements for production of food-grade growth factors, including FGF2 and insulin. It currently is progressing through essential stages of securing approval from the Ministry of Health for food manufacturing licensing. The company is committed to scalability, adhering to ISO2200 and HACCP standards.

"We more than doubled our workforce from 23 to 50 workers to advance all aspects of production, cultivation, and R&D," reports Yaari. "We stimulate the commercial aspirations of cultivated meat start-ups and the pilot plant signifies a substantial step toward the company's next growth stage in 2025: the capacity for processing 25 tons of leaves daily, reaching commercial production of five tons annually by the end of 2025."

A growing future
BioBetter also made breakthroughs in the cultivation of bovine insulin-expressing plants. Several thousand square meters of FGF2-expressing tobacco plants are already thriving in northern Israel. It's the first time growth factor sources have been successfully planted in large net-houses, in four locations, and with a fruitful harvest obtained in its first season. Plans are underway to cultivate more FGF2 and insulin-expressing plants, with commercial roll-out projected for 2024.

"Over the past year, our outreach and collaborations expanded considerably," adds Yarden. "We've shared GF samples with numerous cultivated meat companies and cell media producers worldwide and received promising proof-of-concept results for both our FGF2 and insulin from several companies and academic laboratories." The USD250 million global cultivated meat sector is poised for substantial growth, yet its realization hinges upon a significant supply of growth factors.

"The most significant challenge of the cultivated meat industry is to produce and scale up at the right cost," notes Aviv Oren, Director of Business Engagement and Innovation, the Good Food Institute, Israel. "Biobetter's technology, which is based on molecular farming of food-grade growth factors in the required quantities and costs for industrial production, is a pivotal addition that has the potential to accelerate this industry. We are following BioBetter's progress and hope that its products will soon reach the market."

In 2022, BioBetter secured USD10 million in A-round investment led by Jerusalem Venture Partners (JVP). The company also is an active member of the Israeli Cultivated Meat Consortium, which unites academic institutions, large companies, and start-ups to collaboratively advance the field of cultivated meat.

Biobetter will be participating in the Good Food Conference 2023, 18-20 September in San Francisco.

About BioBetter
BioBetter was founded by Oded Shoseyov, Ph.D., an entrepreneur and researcher at The Hebrew University in Jerusalem; Dana Yarden M.D., MBA, a biotech business expert; and Avi Tzur, an industrialist with an avid vision to put tobacco plants to positive use and the first investor in the technology. The CEO, Amit Yaari, Ph.D., joined in 2016 and co-authored the core technology patents. BioBetter pioneers novel protein expression platforms to address the fast-growing demand for complex recombinant proteins. The new technology will alleviate one of the biggest bottlenecks in advancing cultured meat to mass production. The start-up is a winner of several awards and grants including the joint GFI-EIT Cultivated Meat Innovation Challenge (Sept 2022) and the 2022 FoodTech Calcalist and Tnuva competition.

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